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BIO 200 Endoplasmic Reticulum Lumen & Membrane Question

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A physician hypothesizes that a patient has eaten a toxin that destroys most cellular SRP. Which of the following observations would confirm the hypothesis?

An increase in vesicle formation.

An increase in secreted proteins.

An increase in proteins in the cytosol.

An increase in proteins in the endoplasmic reticulum lumen.